Biology AS OCR
-
1-1-practical-skills-written-assessment AS7 主题
-
1-2-practical-skills-endorsement-assessment AS16 主题
-
1-2-1-practical-ethical-use-of-organisms as
-
1-2-2-practical-aseptic-techniques as
-
1-2-3-practical-dissection-of-gas-exchange-surfaces-in-fish-and-insects as
-
1-2-4-drawing-cells-from-blood-smears as
-
1-2-5-practical-investigating-biodiversity-using-sampling as
-
1-2-6-practical-data-loggers-and-computer-modelling as
-
1-2-7-practical-investigating-the-rate-of-diffusion as
-
1-2-8-practical-investigating-water-potential as
-
1-2-9-practical-factors-affecting-membrane-structure-and-permeability as
-
1-2-10-biochemical-tests-reducing-sugars-and-starch as
-
1-2-11-biochemical-tests-lipids as
-
1-2-12-biochemical-tests-proteins as
-
1-2-13-chromatography as
-
1-2-14-serial-dilutions as
-
1-2-15-practical-investigating-the-rate-of-transpiration as
-
1-2-16-practical-using-a-light-microscope as
-
1-2-1-practical-ethical-use-of-organisms as
-
2-1-cell-structure AS9 主题
-
2-1-2-using-a-microscope as
-
2-1-3-drawing-cells as
-
2-1-4-magnification-and-resolution as
-
2-1-5-eukaryotic-cells as
-
2-1-6-eukaryotic-cells-under-the-microscope as
-
2-1-7-organelles-and-the-production-of-proteins as
-
2-1-8-the-cytoskeleton as
-
2-1-9-prokaryotic-and-eukaryotic-cells as
-
2-1-1-studying-cells as
-
2-1-2-using-a-microscope as
-
2-2-biological-molecules AS17 主题
-
2-2-1-properties-of-water as
-
2-2-2-monomers-and-polymers as
-
2-2-3-monosaccharides as
-
2-2-4-the-glycosidic-bond as
-
2-2-5-polysaccharides as
-
2-2-6-biochemical-tests-reducing-sugars-and-starch as
-
2-2-7-lipids-and-ester-bonds as
-
2-2-8-lipids-structure-and-function as
-
2-2-9-biochemical-tests-lipids as
-
2-2-10-amino-acids-and-peptide-bonds as
-
2-2-11-protein-structure as
-
2-2-12-globular-proteins as
-
2-2-13-fibrous-proteins as
-
2-2-14-inorganic-ions as
-
2-2-15-biochemical-tests-proteins as
-
2-2-16-finding-the-concentration-of-a-substance as
-
2-2-17-chromatography as
-
2-2-1-properties-of-water as
-
2-3-nucleotides-and-nucleic-acids AS8 主题
-
2-4-enzymes AS9 主题
-
2-4-1-the-role-of-enzymes as
-
2-4-2-enzyme-action as
-
2-4-3-enzyme-activity-ph as
-
2-4-4-enzyme-activity-temperature as
-
2-4-5-enzyme-activity-enzyme-concentration as
-
2-4-6-enzyme-activity-substrate-concentration as
-
2-4-7-enzyme-activity-enzyme-inhibitors as
-
2-4-8-coenzymes-cofactors-and-prosthetic-groups as
-
2-4-9-practical-measuring-enzyme-activity as
-
2-4-1-the-role-of-enzymes as
-
2-5-biological-membranes AS9 主题
-
2-5-1-the-cell-surface-membrane as
-
2-5-2-membrane-structure-and-permeability as
-
2-5-3-diffusion-and-facilitated-diffusion as
-
2-5-4-practical-investigating-the-rate-of-diffusion as
-
2-5-5-active-transport as
-
2-5-6-endocytosis-and-exocytosis as
-
2-5-7-osmosis as
-
2-5-8-osmosis-in-animal-and-plant-cells as
-
2-5-9-practical-investigating-water-potential as
-
2-5-1-the-cell-surface-membrane as
-
2-6-cell-division-cell-diversity-and-cellular-organisation AS11 主题
-
2-6-1-the-cell-cycle as
-
2-6-2-the-stages-of-mitosis as
-
2-6-3-identifying-mitosis-in-plant-cells as
-
2-6-4-the-significance-of-mitosis as
-
2-6-5-the-stages-of-meiosis as
-
2-6-6-the-significance-of-meiosis as
-
2-6-7-specialised-cells as
-
2-6-8-the-organisation-of-cells as
-
2-6-9-stem-cells as
-
2-6-10-stem-cells-in-animals-and-plants as
-
2-6-11-the-use-of-stem-cells as
-
2-6-1-the-cell-cycle as
-
3-1-exchange-surfaces AS7 主题
-
3-2-transport-in-animals AS12 主题
-
3-2-1-the-need-for-transport-systems-in-animals as
-
3-2-2-circulatory-systems as
-
3-2-3-blood-vessels as
-
3-2-4-tissue-fluid as
-
3-2-5-the-mammalian-heart as
-
3-2-6-practical-mammalian-heart-dissection as
-
3-2-7-the-cardiac-cycle as
-
3-2-8-cardiac-output as
-
3-2-9-heart-action-initiation-and-control as
-
3-2-10-electrocardiograms-ecgs as
-
3-2-11-the-role-of-haemoglobin as
-
3-2-12-adult-and-fetal-haemoglobin as
-
3-2-1-the-need-for-transport-systems-in-animals as
-
3-3-transport-in-plants AS11 主题
-
3-3-1-the-need-for-transport-systems-in-plants as
-
3-3-2-the-xylem-and-phloem as
-
3-3-3-the-xylem as
-
3-3-4-the-phloem as
-
3-3-5-transverse-sections-stems-roots-and-leaves as
-
3-3-6-the-process-of-transpiration as
-
3-3-7-transpiration-in-plants as
-
3-3-8-practical-investigating-the-rate-of-transpiration as
-
3-3-9-translocation as
-
3-3-10-the-mass-flow-hypothesis as
-
3-3-11-the-adaptations-of-xerophytic-and-hydrophytic-plants as
-
3-3-1-the-need-for-transport-systems-in-plants as
-
4-1-communicable-diseases-disease-prevention-and-the-immune-system AS16 主题
-
4-1-1-common-pathogens-and-communicable-diseases as
-
4-1-2-transmission-of-communicable-pathogens as
-
4-1-3-plant-defences-against-pathogens as
-
4-1-4-non-specific-immune-responses as
-
4-1-5-phagocytes as
-
4-1-6-blood-cells as
-
4-1-7-the-t-lymphocyte-response as
-
4-1-8-the-b-lymphocyte-response as
-
4-1-9-primary-and-secondary-immune-responses as
-
4-1-10-antibodies as
-
4-1-11-opsonins-agglutinins-and-anti-toxins as
-
4-1-12-types-of-immunity as
-
4-1-13-autoimmune-diseases as
-
4-1-14-principles-of-vaccination as
-
4-1-15-sources-of-medicine as
-
4-1-16-antibiotics as
-
4-1-1-common-pathogens-and-communicable-diseases as
-
4-2-biodiversity AS10 主题
-
4-2-1-biodiversity as
-
4-2-2-sampling-to-determine-biodiversity as
-
4-2-3-practical-investigating-biodiversity-using-sampling as
-
4-2-4-measuring-species-richness-and-species-evenness as
-
4-2-5-simpsons-index as
-
4-2-6-genetic-diversity as
-
4-2-7-factors-affecting-biodiversity as
-
4-2-8-reasons-for-maintaining-biodiversity as
-
4-2-9-methods-of-maintaining-biodiversity as
-
4-2-10-conservation-agreements as
-
4-2-1-biodiversity as
-
4-3-classification-and-evolution AS15 主题
-
4-3-1-classification-of-species as
-
4-3-2-binomial-system as
-
4-3-3-classification-of-the-three-domains as
-
4-3-4-classification-of-the-five-kingdoms as
-
4-3-5-classification-and-phylogeny as
-
4-3-6-evidence-of-evolution as
-
4-3-7-types-of-variation as
-
4-3-8-standard-deviation as
-
4-3-9-variation-t-test-method as
-
4-3-10-variation-t-test-worked-example as
-
4-3-11-spearmans-rank-correlation as
-
4-3-12-adaptation as
-
4-3-13-natural-selection as
-
4-3-14-evolution-of-resistance as
-
4-3-15-consequences-of-resistance as
-
4-3-1-classification-of-species as
3-2-7-the-cardiac-cycle as
Exam code:H020
The cardiac cycle
-
The cardiac cycle is the series of events that take place in one heart beat, including muscle contraction and relaxation
-
The contraction of the heart is called systole, while the relaxation of the heart is called diastole
-
-
One cardiac cycle is followed by another in a continuous process
-
There is no gap between cycles where blood stops flowing
-
Volume and pressure changes
-
Volume changes occur in the heart during the cardiac cycle
-
Contraction of the heart muscle causes a decrease in volume in the corresponding chamber of the heart, which then increases again when the muscle relaxes
-
-
Volume changes lead to corresponding pressure changes
-
When volume decreases, pressure increases
-
When volume increases, pressure decreases
-
The events of the cardiac cycle
Atrial systole
-
The walls of the atria contract
-
Atrial volume decreases
-
Atrial pressure increases
-
-
The pressure in the atria rises above that in the ventricles, forcing the atrioventricular (AV) valves open
-
Blood is forced into the ventricles
-
There is a slight increase in ventricular pressure and chamber volume as the ventricles receive the blood from the atria
-
-
The ventricles are relaxed at this point; ventricular diastole coincides with atrial systole
Ventricular systole
-
The walls of the ventricles contract
-
Ventricular volume decreases
-
Ventricular pressure increases
-
-
The pressure in the ventricles rises above that in the atria
-
This forces the AV valves to close, preventing back flow of blood
-
-
The pressure in the ventricles rises above that in the aorta and pulmonary artery
-
This forces the semilunar (SL) valves open so blood is forced into the arteries and out of the heart
-
-
During this period, the atria are relaxing; atrial diastole coincides with ventricular systole
-
The blood flow to the heart continues, so the relaxed atria begin to fill with blood again
-
Diastole
-
The ventricles and atria are both relaxed
-
The pressure in the ventricles drops below that in the aorta and pulmonary artery, forcing the SL valves to close
-
The atria continue to fill with blood
-
Blood returns to the heart via the vena cava and pulmonary vein
-
-
Pressure in the atria rises above that in the ventricles, forcing the AV valves open
-
Blood flows passively into the ventricles without need of atrial systole
-
The cycle then begins again with atrial systole

Valve movements during the cardiac cycle
-
Pressure changes cause the valves to open and close in different regions of the heart
-
Valves open when the pressure of blood behind them is greater than the pressure in front of them
-
They close when the pressure of blood in front of them is greater than the pressure behind them
-
|
Stage in cardiac cycle |
Atrioventricular valves |
Semilunar valves |
|---|---|---|
|
Atrial systole |
Open |
Closed |
|
Ventricular systole |
Closed |
Open |
|
Diastole |
Open |
Closed |
Analysing data relating to the cardiac cycle
-
The changes that occur during the cardiac cycle can be shown on a graph, e.g.:
-
The lines on the graph below represent the pressure of the left atrium, aorta, and the left ventricle
-

Interpreting the cardiac cycle graph
-
Point A: the end of diastole
-
The atrium has filled with blood during the preceding diastole
-
Pressure is higher in the atrium than in the ventricle, so the AV valve is open
-
-
Point A-B: atrial systole
-
Left atrium contracts, causing an increase in atrial pressure and forcing blood into the left ventricle
-
Ventricular pressure increases slightly as it fills with blood
-
Pressure is higher in the atrium than in the ventricle, so the AV valve is open
-
-
Point B: beginning of ventricular systole
-
Left ventricle contracts causing the ventricular pressure to increase
-
Pressure in the left atrium drops as the muscle relaxes
-
Pressure in the ventricle exceeds pressure in the atrium, so the AV valve shuts
-
-
Point C: ventricular systole
-
The ventricle continues to contract
-
Pressure in the left ventricle exceeds that in the aorta
-
Aortic valve opens and blood is forced into the aorta
-
-
Point D: beginning of diastole
-
Left ventricle has been emptied of blood
-
Muscles in the walls of the left ventricle relax and pressure falls below that in the newly filled aorta
-
Aortic valve closes
-
-
Point D-E: early diastole
-
The ventricle remains relaxed and ventricular pressure continues to decrease
-
In the meantime, blood is flowing into the relaxed atrium from the pulmonary vein, causing an increase in pressure
-
-
Point E: diastole
-
The relaxed left atrium fills with blood, causing the pressure in the atrium to exceed that in the newly emptied ventricle
-
AV valve opens
-
-
After point E: late diastole
-
There is a short period of time during which the left ventricle expands due to relaxing muscles
-
This increases the internal volume of the left ventricle and decreases the ventricular pressure
-
At the same time, blood is flowing slowly through the newly opened AV valve into the left ventricle, causing a brief decrease in pressure in the left atrium
-
The pressure in both the atrium and ventricle then increases slowly as they continue to fill with blood
-
Worked Example
The graph below shows the cardiac cycle.
Calculate the heart rate of this person. Give your answer in beats per minute.

Answer:
Step 1: work out the length of one heart beat
-
It takes 0.7 seconds for completion of one cardiac cycle, which is one heart beat
1 cycle = 0.7 seconds
Step 2: calculate how many heart beats occur per second
-
Determine the number of times 0.7 fits into 1 second
1 0.7 = 1.43 beats per second
Step 3: calculate how many heart beats occur per minute
-
1 minute = 60 seconds
1.43 x 60 = 85.71 beats beats / min
Examiner Tips and Tricks
Make sure that you can point out the times on a cardiac cycle graph at which different valves are opening and closing.
Responses