Biology AS OCR
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1-1-practical-skills-written-assessment AS7 主题
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1-2-practical-skills-endorsement-assessment AS16 主题
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1-2-1-practical-ethical-use-of-organisms as
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1-2-2-practical-aseptic-techniques as
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1-2-3-practical-dissection-of-gas-exchange-surfaces-in-fish-and-insects as
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1-2-4-drawing-cells-from-blood-smears as
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1-2-5-practical-investigating-biodiversity-using-sampling as
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1-2-6-practical-data-loggers-and-computer-modelling as
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1-2-7-practical-investigating-the-rate-of-diffusion as
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1-2-8-practical-investigating-water-potential as
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1-2-9-practical-factors-affecting-membrane-structure-and-permeability as
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1-2-10-biochemical-tests-reducing-sugars-and-starch as
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1-2-11-biochemical-tests-lipids as
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1-2-12-biochemical-tests-proteins as
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1-2-13-chromatography as
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1-2-14-serial-dilutions as
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1-2-15-practical-investigating-the-rate-of-transpiration as
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1-2-16-practical-using-a-light-microscope as
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1-2-1-practical-ethical-use-of-organisms as
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2-1-cell-structure AS9 主题
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2-1-2-using-a-microscope as
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2-1-3-drawing-cells as
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2-1-4-magnification-and-resolution as
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2-1-5-eukaryotic-cells as
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2-1-6-eukaryotic-cells-under-the-microscope as
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2-1-7-organelles-and-the-production-of-proteins as
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2-1-8-the-cytoskeleton as
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2-1-9-prokaryotic-and-eukaryotic-cells as
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2-1-1-studying-cells as
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2-1-2-using-a-microscope as
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2-2-biological-molecules AS17 主题
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2-2-1-properties-of-water as
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2-2-2-monomers-and-polymers as
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2-2-3-monosaccharides as
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2-2-4-the-glycosidic-bond as
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2-2-5-polysaccharides as
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2-2-6-biochemical-tests-reducing-sugars-and-starch as
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2-2-7-lipids-and-ester-bonds as
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2-2-8-lipids-structure-and-function as
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2-2-9-biochemical-tests-lipids as
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2-2-10-amino-acids-and-peptide-bonds as
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2-2-11-protein-structure as
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2-2-12-globular-proteins as
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2-2-13-fibrous-proteins as
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2-2-14-inorganic-ions as
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2-2-15-biochemical-tests-proteins as
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2-2-16-finding-the-concentration-of-a-substance as
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2-2-17-chromatography as
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2-2-1-properties-of-water as
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2-3-nucleotides-and-nucleic-acids AS8 主题
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2-4-enzymes AS9 主题
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2-4-1-the-role-of-enzymes as
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2-4-2-enzyme-action as
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2-4-3-enzyme-activity-ph as
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2-4-4-enzyme-activity-temperature as
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2-4-5-enzyme-activity-enzyme-concentration as
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2-4-6-enzyme-activity-substrate-concentration as
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2-4-7-enzyme-activity-enzyme-inhibitors as
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2-4-8-coenzymes-cofactors-and-prosthetic-groups as
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2-4-9-practical-measuring-enzyme-activity as
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2-4-1-the-role-of-enzymes as
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2-5-biological-membranes AS9 主题
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2-5-1-the-cell-surface-membrane as
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2-5-2-membrane-structure-and-permeability as
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2-5-3-diffusion-and-facilitated-diffusion as
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2-5-4-practical-investigating-the-rate-of-diffusion as
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2-5-5-active-transport as
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2-5-6-endocytosis-and-exocytosis as
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2-5-7-osmosis as
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2-5-8-osmosis-in-animal-and-plant-cells as
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2-5-9-practical-investigating-water-potential as
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2-5-1-the-cell-surface-membrane as
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2-6-cell-division-cell-diversity-and-cellular-organisation AS11 主题
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2-6-1-the-cell-cycle as
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2-6-2-the-stages-of-mitosis as
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2-6-3-identifying-mitosis-in-plant-cells as
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2-6-4-the-significance-of-mitosis as
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2-6-5-the-stages-of-meiosis as
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2-6-6-the-significance-of-meiosis as
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2-6-7-specialised-cells as
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2-6-8-the-organisation-of-cells as
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2-6-9-stem-cells as
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2-6-10-stem-cells-in-animals-and-plants as
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2-6-11-the-use-of-stem-cells as
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2-6-1-the-cell-cycle as
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3-1-exchange-surfaces AS7 主题
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3-2-transport-in-animals AS12 主题
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3-2-1-the-need-for-transport-systems-in-animals as
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3-2-2-circulatory-systems as
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3-2-3-blood-vessels as
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3-2-4-tissue-fluid as
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3-2-5-the-mammalian-heart as
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3-2-6-practical-mammalian-heart-dissection as
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3-2-7-the-cardiac-cycle as
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3-2-8-cardiac-output as
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3-2-9-heart-action-initiation-and-control as
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3-2-10-electrocardiograms-ecgs as
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3-2-11-the-role-of-haemoglobin as
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3-2-12-adult-and-fetal-haemoglobin as
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3-2-1-the-need-for-transport-systems-in-animals as
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3-3-transport-in-plants AS11 主题
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3-3-1-the-need-for-transport-systems-in-plants as
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3-3-2-the-xylem-and-phloem as
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3-3-3-the-xylem as
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3-3-4-the-phloem as
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3-3-5-transverse-sections-stems-roots-and-leaves as
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3-3-6-the-process-of-transpiration as
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3-3-7-transpiration-in-plants as
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3-3-8-practical-investigating-the-rate-of-transpiration as
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3-3-9-translocation as
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3-3-10-the-mass-flow-hypothesis as
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3-3-11-the-adaptations-of-xerophytic-and-hydrophytic-plants as
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3-3-1-the-need-for-transport-systems-in-plants as
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4-1-communicable-diseases-disease-prevention-and-the-immune-system AS16 主题
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4-1-1-common-pathogens-and-communicable-diseases as
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4-1-2-transmission-of-communicable-pathogens as
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4-1-3-plant-defences-against-pathogens as
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4-1-4-non-specific-immune-responses as
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4-1-5-phagocytes as
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4-1-6-blood-cells as
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4-1-7-the-t-lymphocyte-response as
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4-1-8-the-b-lymphocyte-response as
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4-1-9-primary-and-secondary-immune-responses as
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4-1-10-antibodies as
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4-1-11-opsonins-agglutinins-and-anti-toxins as
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4-1-12-types-of-immunity as
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4-1-13-autoimmune-diseases as
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4-1-14-principles-of-vaccination as
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4-1-15-sources-of-medicine as
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4-1-16-antibiotics as
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4-1-1-common-pathogens-and-communicable-diseases as
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4-2-biodiversity AS10 主题
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4-2-1-biodiversity as
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4-2-2-sampling-to-determine-biodiversity as
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4-2-3-practical-investigating-biodiversity-using-sampling as
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4-2-4-measuring-species-richness-and-species-evenness as
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4-2-5-simpsons-index as
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4-2-6-genetic-diversity as
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4-2-7-factors-affecting-biodiversity as
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4-2-8-reasons-for-maintaining-biodiversity as
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4-2-9-methods-of-maintaining-biodiversity as
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4-2-10-conservation-agreements as
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4-2-1-biodiversity as
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4-3-classification-and-evolution AS15 主题
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4-3-1-classification-of-species as
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4-3-2-binomial-system as
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4-3-3-classification-of-the-three-domains as
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4-3-4-classification-of-the-five-kingdoms as
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4-3-5-classification-and-phylogeny as
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4-3-6-evidence-of-evolution as
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4-3-7-types-of-variation as
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4-3-8-standard-deviation as
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4-3-9-variation-t-test-method as
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4-3-10-variation-t-test-worked-example as
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4-3-11-spearmans-rank-correlation as
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4-3-12-adaptation as
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4-3-13-natural-selection as
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4-3-14-evolution-of-resistance as
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4-3-15-consequences-of-resistance as
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4-3-1-classification-of-species as
2-6-2-the-stages-of-mitosis as
Exam code:H020
Stages of Mitosis
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Mitosis is the process of nuclear division by which two genetically identical daughter nuclei are produced that are also genetically identical to the parent cell nucleus (they have the same number of chromosomes as the parent cell)
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Although mitosis is, in reality, one continuous process, it can be divided into four main stages
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These stages are:
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Prophase
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Metaphase
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Anaphase
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Telophase
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Most organisms contain many chromosomes in the nuclei of their cells (eg. humans have 46) but the diagrams below show mitosis of an animal cell with only four chromosomes, for simplicity
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The different colours of the chromosomes are just to show that half are from the female parent and half from the male parent
Prophase
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Chromosomes condense and are now visible when stained
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The chromosomes consist of two identical chromatids called sister chromatids (each containing one DNA molecule) that are joined together at the centromere
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The two centrosomes (replicated in the G2 phase just before prophase) move towards opposite poles
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Spindle fibres (protein microtubules) begin to emerge from the centrosomes (consists of two centrioles in animal cells)
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The nuclear envelope (nuclear membrane) breaks down into small vesicles
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The nucleolus disappears
Prophase
Metaphase
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Centrosomes reach opposite poles
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Spindle fibres (protein microtubules) continue to extend from centrosomes
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Chromosomes line up at the equator of the spindle (also known as the metaphase plate) so they are equidistant to the two centrosome poles
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Spindle fibres (protein microtubules) reach the chromosomes and attach to the centromeres
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This attachment involves specific proteins called kinetochores
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Each sister chromatid is attached to a spindle fibre originating from opposite poles
Metaphase
Anaphase
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The sister chromatids separate at the centromere (the centromere divides in two)
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Spindle fibres (protein microtubules) begin to shorten
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The separated sister chromatids (now called chromosomes) are pulled to opposite poles by the spindle fibres (protein microtubules)
Anaphase
Telophase
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Chromosomes arrive at opposite poles and begin to decondense
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Nuclear envelopes (nuclear membranes) begin to reform around each set of chromosomes
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The spindle fibres break down
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New nucleoli form within each nucleus
Telophase
Examiner Tips and Tricks
Make sure you learn the four stages of mitosis and what is happening to the DNA molecules (one chromatid contains one DNA molecule) at each stage – learn ‘PMAT’ (prophase, metaphase, anaphase, telophase) to help you remember the order of the stages!After interphase but before the parent cell undergoes mitosis, the human parent cell nucleus actually contains 92 DNA molecules! This is because during interphase (S phase), the 46 DNA molecules in the parent cell have replicated to form sister chromatids. As human cells have a diploid number of 46 this replication results in 92 molecules. This ensures the two daughter cells will be diploid (have 46 chromosomes each) when mitosis occurs.Remember to read the questions carefully as only human diploid cells have 46 chromosomes so if the question refers to another organism, its diploid number will be different.
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