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Biology AS CIE

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  1. 1-cell-structure
    10 主题
  2. 2-biological-molecules
    19 主题
  3. 3-enzymes
    13 主题
  4. 4-cell-membranes-and-transport
    16 主题
  5. 5-the-mitotic-cell-cycle
    8 主题
  6. 6-nucleic-acids-and-protein-synthesis
    9 主题
  7. 7-transport-in-plants
    11 主题
  8. 8-transport-in-mammals
    16 主题
  9. 9-gas-exchange
    6 主题
  10. 10-infectious-diseases
    6 主题
  11. 11-immunity
    10 主题
课 8, 主题 8
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8-2-transport-of-oxygen-and-carbon-dioxide AS the-chloride-shift

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Exam code:9700

The Chloride Shift

  • The chloride shift is the movement of chloride ions into red blood cells that occurs when hydrogencarbonate ions are formed

  • Hydrogencarbonate ions are formed by the following process:

    • Carbon dioxide diffuses into red blood cells 

    • The enzyme carbonic anhydrase catalyses the combining of carbon dioxide and water to form carbonic acid (H2CO3)

CO2 + H2O ⇌ H2CO3 

  • Carbonic acid dissociates to form hydrogen carbonate ions and hydrogen ions

H2CO3 ⇌ HCO3 + H+

  • Negatively charged hydrogencarbonate ions formed from the dissociation of carbonic acid are transported out of red blood cells via a transport protein in the membrane

  • To prevent an electrical imbalance, negatively charged chloride ions are transported into the red blood cells via the same transport protein

    • If this did not occur then red blood cells would become positively charged as a result of a build up of hydrogen ions formed from the dissociation of carbonic acid

Examiner Tips and Tricks

Be sure to learn the differences between the Bohr shift and chloride shift. The Bohr shift occurs when a high partial pressure of carbon dioxide causes haemoglobin to release oxygen into respiring tissues, while the chloride shift refers to the movement of chloride ions into red blood cells.

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