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Biology AS CIE

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  1. 1-cell-structure
    10 主题
  2. 2-biological-molecules
    19 主题
  3. 3-enzymes
    13 主题
  4. 4-cell-membranes-and-transport
    16 主题
  5. 5-the-mitotic-cell-cycle
    8 主题
  6. 6-nucleic-acids-and-protein-synthesis
    9 主题
  7. 7-transport-in-plants
    11 主题
  8. 8-transport-in-mammals
    16 主题
  9. 9-gas-exchange
    6 主题
  10. 10-infectious-diseases
    6 主题
  11. 11-immunity
    10 主题
课 5, 主题 5
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5-1-replication-and-division-of-nuclei-and-cells AS the-role-of-telomeres-

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Exam code:9700

The significance of telomeres

  • The ends of the chromatids in chromosomes are ‘sealed’ with protective structures called telomeres

    • They are made of non-coding DNA (DNA that does not contain genes) that is made up of short base sequences that are repeated many times (multiple repeat sequences)

  • The main function of telomeres is to ensure that the very ends of the DNA molecules are included in DNA replication during mitosis

    • This is because the copying enzyme responsible for DNA replication is unable to run right to the very end of the DNA molecule and stops a little short of the end

    • If this end part of the DNA molecule contained an important gene, that piece of genetic information would be lost during DNA replication

    • In each subsequent cell division, a little more genetic information would be lost

  • Telomeres therefore act as a ‘buffer’ region of non-essential DNA

    • They ensure that no important coding sections near the ends of the DNA molecules are left out of the replication process

    • This ensures no genes are lost during cell division (the loss of vital genes can even result in cell death) and allows for continued replication of a cell

Diagram of a chromosome highlighting a telomere with repeat DNA sequences. Labels indicate guanine and cytosine-rich strands, and chromatid.
A telomere with multiple repeat sequences

Examiner Tips and Tricks

Telomeres are similar to the coding regions of DNA molecules in that they are made of the same nucleotides. However, telomeres’ base sequences are non-coding, meaning they do not code for proteins.

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