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  1. 1-1-biological-molecules-carbohydrates
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  10. 2-4-cell-membranes-and-transport
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  11. 2-5-cell-recognition-and-the-immune-system
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  12. 2-6-vaccines-disease-and-monoclonal-antibodies
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  13. 3-1-adaptations-for-gas-exchange
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  14. 3-2-human-gas-exchange
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  15. 3-3-digestion-and-absorption
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  17. 3-5-the-circulatory-system-in-animals
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  19. 4-1-dna-genes-and-chromosomes
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  21. 4-3-genetic-diversity-mutations-and-meiosis
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  22. 4-4-genetic-diversity-and-adaptation
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  23. 4-5-species-and-taxonomy
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  24. 4-6-biodiversity
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Exam code:7401

Phagocytosis

  • Phagocytes are white blood cells that are produced continuously in the bone marrow

  • There are two main types of phagocyte, each with a specific mode of action:

    • neutrophils

    • macrophages

  • The role of phagocytes is to recognise and engulf pathogens; this process is known as phagocytosis

  • Phagocytosis is an example of a non-specific immune response

The process of phagocytosis

  1. Chemotaxis – Chemicals from pathogens or damaged body cells (e.g. histamines) attract phagocytes to the infection site

  2. Recognition and attachment

    1. Phagocytes detect non-self antigens on pathogens using receptor proteins on their membrane

    2. Receptors bind to antigens on the pathogen’s surface

  3. Engulfment – The phagocyte’s membrane extends around the pathogen, forming a phagocytic vacuole (this is an example of endocytosis)

  4. Phagosome formation – The vacuole containing the pathogen is now called a phagosome

  5. Phagolysosome formation – The phagosome fuses with a lysosome, forming a phagolysosome

  6. Digestion – Lysozymes (digestive enzymes) are released to hydrolyse the pathogen (e.g. breaking down bacterial cell walls)

  7. Antigen presentation – In macrophages, digested pathogen fragments may be displayed on the cell surface to activate the specific immune response

Flowchart of neutrophil phagocytosis showing attraction, attachment, endocytosis, digestion, and antigen presentation with labelled diagrams.
Phagocytosis and antigen presentation

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